Article
A predictive model for life-threatening fluoropyrimidine toxicity based on DPYD sequencing in colorectal cancer.
Journal of the National Cancer Institute - 1 Apr 2026
Boige Valérie, Menoret Estelle, Le Teuff Gwénaël, Boyer Jean-Christophe, Cozic Nathalie, Desvignes Jean-Pierre, Taieb Julien, Laurent-Puig Pierre, Wettergren Yvonne, Schwab Matthias, Ackland Stephen, Jennings Barbara, Sudaka Anne, Seutin Eva, Beroud Christophe, Koudou Yves, Etienne-Grimaldi Marie-Christine
Abstract excerpt
BACKGROUND: Deleterious DPYD variants are the primary identified cause of severe fluoropyrimidine-related toxicity. The objective was to improve the sensitivity of current DPYD genotyping recommendations and develop a predictive model for severe toxicity. METHODS: This pooled analysis included colorectal cancer (CRC) patients from 7 prospective studies. Full DPYD sequencing was performed. Depending on their minor...
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