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Article

Influence of DPYD gene polymorphisms on 5-Fluorouracil toxicities in Thai colorectal cancer patients.

Cancer chemotherapy and pharmacology - 9 Dec 2024

Atasilp Chalirmporn, Vanwong Natchaya, Yodwongjane Pavitchaya, Chansriwong Phichai, Sirachainan Ekaphop, Reungwetwattana Thanyanan, Jinda Pimonpan, Aiempradit Somthawin, Sirilerttrakul Suwannee, Chamnanphon Monpat, Puangpetch Apichaya, Sankuntaw Nipaporn, Satapornpong Patompong, Fabienne Thomas, Sukasem Chonlaphat

Abstract excerpt

DPYD polymorphisms have been widely found to be related to 5-FU-induced toxicities. The aim of this study was to establish significant associations between five single-nucleotide polymorphisms of DPYD and 5-FU hematological toxicities in Thai colorectal cancer patients. The toxicities were analyzed at the first and second cycles of 5-FU administration in 75 patients. Genotyping was performed using TaqMan...

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Identifiers

PMID: 39652193
DOI: 10.1007/s00280-024-04722-z
PMCID: PMC11628428

Genes

DPYD

Provenance

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Influence of DPYD gene polymorphisms on 5-Fluorouracil toxicities in Thai colorectal cancer patients.PMID 39652193Read ↗

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