Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CAPN1 (Calpain1)-Mediated Impairment of Autophagic Flux Contributes to Cerebral Ischemia-Induced Neuronal Damage

20 Apr 2021

Abstract excerpt

Background and Purpose: CAPN1 (calpain1)—an intracellular Ca2+-regulated cysteine protease—can be activated under cerebral ischemia. However, the mechanisms by which CAPN1 activation promotes cerebral ischemic injury are not defined. Methods: In the present study, we used adeno-associated virus-mediated genetic knockdown and pharmacological blockade (MDL-28170) of CAPN1 to investigate the role of CAPN1 in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Calpain Protease Function and Regulation
Share to Cell death mechanisms and regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33874744
DOI: 10.1161/strokeaha.120.032749

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CAPN1 (Calpain1)-Mediated Impairment of Autophagic Flux Contributes to Cerebral Ischemia-Induced Neuronal DamagePMID 33874744Read ↗

The Calpain System as a Modulator of Stress/Damage ResponseSemantic proximity Read ↗

Apoptosis meets autophagy-like cell death in the ischemic penumbra: Two sides of the same coin?Semantic proximity Read ↗

Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell deathSemantic proximity Read ↗

Down-regulation of parkin protein in transient focal cerebral ischemia: A link between stroke and degenerative disease?Semantic proximity Read ↗

Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis.Semantic proximity Read ↗

Catalytically inactive RIP1 and RIP3 deficiency protect against acute ischemic stroke by inhibiting necroptosis and neuroinflammation.Semantic proximity Read ↗

Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans.Semantic proximity Read ↗

[IMMP2L gene mutation activates mitochondrial apoptotic pathway to aggravate cerebral ischemic injury in mice].Semantic proximity Read ↗

Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury.Semantic proximity Read ↗

Histone acetylation and CREB binding protein are required for neuronal resistance against ischemic injury.Semantic proximity Read ↗

Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death.Semantic proximity Read ↗

Immp2l Mutation Induces Mitochondrial Membrane Depolarization and Complex III Activity Suppression after Middle Cerebral Artery Occlusion in Mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.