Article
Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury.
PloS one - 1 Jan 2012
Dvoriantchikova Galina, Ivanov Dmitry, Barakat David, Grinberg Alexander, Wen Rong, Slepak Vladlen Z, Shestopalov Valery I
Abstract excerpt
Pannexin1 (Panx1) forms large nonselective membrane channel that is implicated in paracrine and inflammatory signaling. In vitro experiments suggested that Panx1 could play a key role in ischemic death of hippocampal neurons. Since retinal ganglion cells (RGCs) express high levels of Panx1 and are susceptible to ischemic induced injury, we hypothesized that Panx1 contributes to rapid and selective loss of these...
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