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Article

Catalytically inactive RIP1 and RIP3 deficiency protect against acute ischemic stroke by inhibiting necroptosis and neuroinflammation.

Cell death & disease - 23 Jul 2020

Zhang Yue, Li Ming, Li Xiaoming, Zhang Haiwei, Wang Lingxia, Wu Xiaoxia, Zhang Haibing, Luo Yan

Abstract excerpt

Necroptosis, which is mediated by RIP1/RIP3/MLKL (receptor-interacting protein kinase 1/receptor-interacting protein kinase 3/mixed lineage kinase domain-like protein) signaling, is a critical process in the development of acute ischemic stroke. However, it is unclear precisely how necroptosis promotes the pathogenesis of acute ischemic stroke. In this experimental study in mice, we investigated how necroptosis...

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Identifiers

PMID: 32703968
DOI: 10.1038/s41419-020-02770-w
PMCID: PMC7378260

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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