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Article

Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes.

The Journal of experimental medicine - 4 Jan 1999

Shaw A C, Swat W, Ferrini R, Davidson L, Alt F W

Abstract excerpt

To elucidate the intracellular pathways that mediate early B cell development, we directed expression of activated Ras to the B cell lineage in the context of the recombination-activating gene 1 (RAG1)-deficient background (referred to as Ras-RAG). Similar to the effects of an immunoglobulin (Ig) mu heavy chain (HC) transgene, activated Ras caused progression of RAG1-deficient progenitor (pro)-B cells to cells...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9874569
DOI: 10.1084/jem.189.1.123
PMCID: PMC1887686

Genes

RAG1
RAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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