Article
Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes.
The Journal of experimental medicine - 4 Jan 1999
Shaw A C, Swat W, Ferrini R, Davidson L, Alt F W
Abstract excerpt
To elucidate the intracellular pathways that mediate early B cell development, we directed expression of activated Ras to the B cell lineage in the context of the recombination-activating gene 1 (RAG1)-deficient background (referred to as Ras-RAG). Similar to the effects of an immunoglobulin (Ig)...
Topics
- Animals
- B-Lymphocytes
- Cell Differentiation
- Cell Survival
- DNA-Binding Proteins
- Enzyme Activation
- Gene Expression Regulation, Developmental
- Genes, RAG-1
- Immunoglobulin Heavy Chains
- Immunoglobulin kappa-Chains
- Mice
- Mice, Knockout
- Phenotype
- RNA, Messenger
- Stem Cells
- Transcription, Genetic
- Up-Regulation
- ras Proteins