Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling Maturity Onset Diabetes of the Young in Pluripotent Stem Cells: Challenges and Achievements.

Frontiers in endocrinology - 1 Jan 2021

Braverman-Gross Carmel, Benvenisty Nissim

Abstract excerpt

Maturity onset diabetes of the young (MODY), is a group of monogenic diabetes disorders. Rodent models for MODY do not fully recapitulate the human phenotypes, calling for models generated in human cells. Human pluripotent stem cells (hPSCs), capable of differentiation towards pancreatic cells, possess a great opportunity to model MODY disorders in vitro. Here, we review the models for MODY diseases in hPSCs to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Diabetes Mellitus, Type 2
Share to Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pluripotent Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 33692757
DOI: 10.3389/fendo.2021.622940
PMCID: PMC7937923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling Maturity Onset Diabetes of the Young in Pluripotent Stem Cells: Challenges and Achievements.PMID 33692757Read ↗

Monogenic Diabetes Modeling: In Vitro Pancreatic Differentiation From Human Pluripotent Stem Cells Gains MomentumSemantic proximity Read ↗

Human Pluripotent Stem Cells to Model Islet Defects in Diabetes.Semantic proximity Read ↗

Maturity Onset Diabetes of the Young—New Approaches for Disease ModellingSemantic proximity Read ↗

Toward Precision Medicine with Human Pluripotent Stem Cells for DiabetesSemantic proximity Read ↗

Potential of pluripotent stem cells for diabetes therapy.Semantic proximity Read ↗

Maturity-onset diabetes of the young (MODY) - in search of ideal diagnostic criteria and precise treatment.Semantic proximity Read ↗

Human Pluripotent Stem Cells Go Diabetic: A Glimpse on Monogenic Variants.Semantic proximity Read ↗

Maturity-onset diabetes of the young: From a molecular basis perspective toward the clinical phenotype and proper management.Semantic proximity Read ↗

Derivation of Human Induced Pluripotent Stem Cells from Patients with Maturity Onset Diabetes of the Young*Semantic proximity Read ↗

Stepwise differentiation of functional pancreatic β cells from human pluripotent stem cellsSemantic proximity Read ↗

Towards a Functional Cure for Diabetes Using Stem Cell-Derived Beta Cells: Are We There Yet?Semantic proximity Read ↗

Pluripotent Stem Cells as a Potential Tool for Disease Modelling and Cell Therapy in DiabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.