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Mutant p53 as a Regulator and Target of Autophagy

3 Feb 2021

Abstract excerpt

One of the most notoriously altered genes in human cancer is the tumor-suppressor TP53, which is mutated with high frequency in more cancers than any other tumor suppressor gene. Beyond the loss of wild-type p53 functions, mutations in the TP53 gene often lead to the expression of full-length proteins with new malignant properties. Among the defined oncogenic functions of mutant p53 is its effect on cell...

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PMID: 33614491
DOI: 10.3389/fonc.2020.607149

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