Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel tissue specific alternative splicing variant mitigates phenotypes in Ets2 frame-shift mutant models.

Scientific reports - 15 Apr 2021

Kishimoto Yuki, Nishiura Iori, Hirata Wataru, Yuri Shunsuke, Yamamoto Nami, Ikawa Masahito, Isotani Ayako

Abstract excerpt

E26 avian leukemia oncogene 2, 3' domain (Ets2) has been implicated in various biological processes. An Ets2 mutant model (Ets2db1/db1), which lacks the DNA-binding domain, was previously reported to exhibit embryonic lethality caused by a trophoblast abnormality. This phenotype could be rescued by tetraploid complementation, resulting in pups with wavy hair and curly whiskers. Here, we generated new Ets2 mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR-Cas Systems
Share to Embryo Loss

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Development

Share to Frameshift Mutation

Share to Gene Editing

Share to RNA Splicing

Share to Trophoblasts

Source

Open in PubMed Open full text

Identifiers

PMID: 33859300
DOI: 10.1038/s41598-021-87751-5
PMCID: PMC8050053

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel tissue specific alternative splicing variant mitigates phenotypes in Ets2 frame-shift mutant models.PMID 33859300Read ↗

Generation of a recessive dystrophic epidermolysis bullosa mouse model with patient-derived compound heterozygous mutations.Semantic proximity Read ↗

Hypomorphic phenotype of Foxn1 gene-modified rats by CRISPR/Cas9 system.Semantic proximity Read ↗

Molecular Insights Into the Causes of Human Thymic Hypoplasia With Animal Models.Semantic proximity Read ↗

Two oppositely-charged sf3b1 mutations cause defective development, impaired immune response, and aberrant selection of intronic branch sites in Drosophila.Semantic proximity Read ↗

Genetic modulation of RNA splicing rescues BRCA2 function in mutant cells.Semantic proximity Read ↗

Defective trophoblast function in mice with a targeted mutation of Ets2.Semantic proximity Read ↗

Mutations in a delta 8-delta 7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. jderry@immunex.com.Semantic proximity Read ↗

Construction and functional analysis of novel dominant-negative mutant of human SOX18 protein.Semantic proximity Read ↗

Generation of an Fgf9 conditional null allele.Semantic proximity Read ↗

A Mutation of the Prdm9 Mouse Hybrid Sterility Gene Carried by a Transgene.Semantic proximity Read ↗

Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations.Semantic proximity Read ↗

An ENU-induced mutation in Twist1 transactivation domain causes hindlimb polydactyly with complete penetrance and dominant-negatively impairs E2A-dependent transcription.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.