Article
Inherited cancer predisposing mutations in patients with therapy-related myeloid neoplasms.
British journal of haematology - 1 Feb 2023
Shih Andrew J, Jun Tomi, Skol Andrew D, Bao Riyue, Huang Lei, Vora Sapana, McNerney Megan E, Hungate Eric A, Le Beau Michelle M, Larson Richard A, Elliott Aaron, Lu Hsiao-Mei, Huether Robert, Hernandez Felicia, Stölzel Friedrich, Allan James M, Onel Kenan
Abstract excerpt
Some patients with therapy-related myeloid neoplasms (t-MN) may have unsuspected inherited cancer predisposition syndrome (CPS). We propose a set of clinical criteria to identify t-MN patients with high risk of CPS (HR-CPS). Among 225 t-MN patients with an antecedent non-myeloid malignancy, our clinical criteria identified 52 (23%) HR-CPS patients. Germline whole-exome sequencing identified pathogenic or likely...
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