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Article

Clinical utility of targeted next-generation sequencing for the diagnosis of myeloid neoplasms with germline predisposition.

Molecular oncology - 1 Sept 2021

Andrés-Zayas Cristina, Suárez-González Julia, Rodríguez-Macías Gabriela, Dorado Nieves, Osorio Santiago, Font Patricia, Carbonell Diego, Chicano María, Muñiz Paula, Bastos Mariana, Kwon Mi, Díez-Martín José Luis, Buño Ismael, Martínez-Laperche Carolina

Abstract excerpt

Myeloid neoplasms (MN) with germline predisposition (MNGP) are likely to be more common than currently appreciated. Many of the genes involved in MNGP are also recurrently mutated in sporadic MN. Therefore, routine analysis of gene panels by next-generation sequencing provides an effective approach to detect germline variants with clinical significance in patients with hematological malignancies. Gene panel...

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Identifiers

PMID: 33533142
DOI: 10.1002/1878-0261.12921
PMCID: PMC8410541

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