Spectrum of hematological malignancies, clonal evolution and outcomes in 144 Mayo Clinic patients with germline predisposition syndromes.

doi:10.1002/ajh.26321

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Article

Spectrum of hematological malignancies, clonal evolution and outcomes in 144 Mayo Clinic patients with germline predisposition syndromes.

American journal of hematology - 1 Nov 2021

Martin Emma St, Ferrer Alejandro, Mangaonkar Abhishek A, Khan Shakila P, Kohorst Mira A, Joshi Avni Y, Hogan William J, Olteanu Horatiu, Moyer Ann M, Al-Kali Aref, Tefferi Ayalew, Chen Dong, Wudhikarn Kitsada, Go Ronald, Viswanatha David, He Rong, Ketterling Rhett, Nguyen Phuong L, Oliveira Jennifer L, Gangat Naseema, Lasho Terra, Patnaik Mrinal M

Abstract excerpt

Germline predisposition syndromes (GPS) result from constitutional aberrations in tumor suppressive and homeostatic genes, increasing risk for neoplasia in affected kindred. In this study, we present clinical and genomic data on 144 Mayo Clinic patients with GPS; 59 evaluated prospectively using an algorithm-based diagnostic approach in the setting of a dedicated GPS/ inherited bone marrow failure syndrome...

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