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Article

The Diadenylate Cyclase CdaA Is Critical for Borrelia turicatae Virulence and Physiology.

Infection and immunity - 17 May 2021

Jackson-Litteken Clay D, Ratliff C Tyler, Kneubehl Alexander R, Siletti Cheta, Pack Lindsay, Lan Renny, Huynh TuAnh N, Lopez Job E, Blevins Jon S

Abstract excerpt

Relapsing fever (RF), caused by spirochetes of the genus Borrelia, is a globally distributed, vector-borne disease with high prevalence in developing countries. To date, signaling pathways required for infection and virulence of RF Borrelia spirochetes are unknown. Cyclic di-AMP (c-di-AMP), synthesized by diadenylate cyclases (DACs), is a second messenger predominantly found in Gram-positive organisms that is...

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Identifiers

PMID: 33846120
DOI: 10.1128/IAI.00787-20
PMCID: PMC8316131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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