Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TrkA of Streptococcus mitis CCUG31611 binds cyclic di-adenosine monophosphate and is required for growth in low potassium conditions.

Microbiology (Reading, England) - 1 Aug 2025

Vevik Kristina, Sribasgaran Biramitha, Cai Kun, Naemi Ali-Oddin, Pedersen Kaspersen Håkon, Uhlig Silvio, Økstad Ole Andreas, Simm Roger

Abstract excerpt

Cyclic di-adenosine monophosphate (c-di-AMP) is a bacterial second messenger regulating many physiological processes in bacteria. In the oral commensal species Streptococcus mitis, c-di-AMP is involved in regulating metabolism, growth, colony morphology, chain length, biofilm formation and DNA stress tolerance. However, no c-di-AMP-regulated effector proteins have yet been characterized in S. mitis. In this...

Read the complete abstract on PubMed

Topics

Potassium
Bacterial Proteins
Dinucleoside Phosphates
Streptococcus mitis
Gene Expression Regulation, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 40811027
DOI: 10.1099/mic.0.001597
PMCID: PMC12453120

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TrkA of Streptococcus mitis CCUG31611 binds cyclic di-adenosine monophosphate and is required for growth in low potassium conditions.PMID 40811027Read ↗

c-di-AMP-Regulated K+ Importer KtrAB Affects Biofilm Formation, Stress Response, and SpeB Expression in Streptococcus pyogenes.Semantic proximity Read ↗

Binding of Cyclic Di-AMP to the Staphylococcus aureus Sensor Kinase KdpD Occurs via the Universal Stress Protein Domain and Downregulates the Expression of the Kdp Potassium TransporterSemantic proximity Read ↗

Replenishing the cyclic-di-AMP pool: regulation of diadenylate cyclase activity in bacteria.Semantic proximity Read ↗

Identification of the Components Involved in Cyclic Di-AMP Signaling in Mycoplasma pneumoniaeSemantic proximity Read ↗

Cyclic di-AMP regulation of osmotic homeostasis is essential in Group B Streptococcus.Semantic proximity Read ↗

c-di-AMP is essential for the virulence of <i>Enterococcus faecalis</i>Semantic proximity Read ↗

The Diadenylate Cyclase CdaA Is Critical for Borrelia turicatae Virulence and Physiology.Semantic proximity Read ↗

c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficileSemantic proximity Read ↗

Coordinated regulation of osmotic imbalance by c-di-AMP shapes ß-lactam tolerance in Group B <i>Streptococcus</i>Semantic proximity Read ↗

Coordinated regulation of osmotic imbalance by c-di-AMP shapes ß-lactam tolerance in Group B StreptococcusSemantic proximity Read ↗

Enhanced uptake of potassium or glycine betaine or export of cyclic-di-AMP restores osmoresistance in a high cyclic-di-AMP Lactococcus lactis mutant.Semantic proximity Read ↗

Redundant potassium transporter systems guarantee the survival of Enterococcus faecalis under stress conditionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.