Genetic justification of severe COVID-19 using a rigorous algorithm.

doi:10.1016/j.clim.2021.108726

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Article

Genetic justification of severe COVID-19 using a rigorous algorithm.

Clinical immunology (Orlando, Fla.) - 1 May 2021

Gavriilaki Eleni, Asteris Panagiotis G, Touloumenidou Tasoula, Koravou Evaggelia-Evdoxia, Koutra Maria, Papayanni Penelope Georgia, Karali Vassiliki, Papalexandri Apostolia, Varelas Christos, Chatzopoulou Fani, Chatzidimitriou Maria, Chatzidimitriou Dimitrios, Veleni Anastasia, Grigoriadis Savvas, Rapti Evdoxia, Chloros Diamantis, Kioumis Ioannis, Kaimakamis Evaggelos, Bitzani Milly, Boumpas Dimitrios, Tsantes Argyris, Sotiropoulos Damianos, Sakellari Ioanna, Kalantzis Ioannis G, Parastatidis Stefanos T, Koopialipoor Mohammadreza, Cavaleri Liborio, Armaghani Danial J, Papadopoulou Anastasia, Brodsky Robert Alan, Kokoris Styliani, Anagnostopoulos Achilles

Abstract excerpt

Recent studies suggest excessive complement activation in severe coronavirus disease-19 (COVID-19). The latter shares common characteristics with complement-mediated thrombotic microangiopathy (TMA). We hypothesized that genetic susceptibility would be evident in patients with severe COVID-19 (similar to TMA) and associated with disease severity. We analyzed genetic and clinical data from 97 patients hospitalized...

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Identifiers

PMID: 33845193
DOI: 10.1016/j.clim.2021.108726
PMCID: PMC8043057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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