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Article

Genetic Predisposition to Elevated Levels of Circulating ADAM17 Is Associated with the Risk of Severe COVID-19.

International journal of molecular sciences - 1 Nov 2023

Pan Mengyu, Goncalves Isabel, Edsfeldt Andreas, Sun Jiangming, Swärd Per

Abstract excerpt

High levels of ADAM17 activity have emerged as an important mediator in severe COVID-19. This study aims to characterize eventual causal relationships between ADAM17 and COVID-19. Using Mendelian randomization analyses, we examined the causal effects of circulating ADAM17 on COVID-19 outcomes using summary statistics from large, genome-wide association studies of ADAM17 (up to 35,559 individuals) from the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37958866
DOI: 10.3390/ijms242115879
PMCID: PMC10647461

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