Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Examination of ATM, BRCA1, and BRCA2 promoter methylation in patients with pancreatic cancer.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Aug 2021

Zhou Cancan, Porter Nancy, Borges Michael, Gauthier Christian, Ferguson Lindsey, Huang Bo, Nanda Neha, He Jin, Laheru Daniel, Hruban Ralph H, Goggins Michael, Klein Alison P, Roberts Nicholas J

Abstract excerpt

BACKGROUND: Pancreatic cancer is a lethal disease with a poor 5-year survival rate. Pathogenic germline variants in the coding regions of ATM, BRCA1, and BRCA2 are found in up to 4.8% of pancreatic cancer patients. Germline promoter methylation and gene silencing arising from a germline variant or through other mechanisms have been described as a cause of tumor suppressor gene inactivation. METHODS: We measured...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia Mutated Proteins
Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BRCA2 Protein

Share to Breast Neoplasms

Share to DNA Methylation

Share to Genes, BRCA2

Share to Pancreatic Neoplasms

Share to Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 33839031
DOI: 10.1016/j.pan.2021.03.015
PMCID: PMC8355034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Examination of ATM, BRCA1, and BRCA2 promoter methylation in patients with pancreatic cancer.PMID 33839031Read ↗

ATM mutations in patients with hereditary pancreatic cancer.Semantic proximity Read ↗

Risk of Pancreatic Cancer Among Individuals With Pathogenic Variants in the ATM GeneSemantic proximity Read ↗

Characterizing DNA methylation patterns in pancreatic cancer genomeSemantic proximity Read ↗

Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms.Semantic proximity Read ↗

The Frequency of Germline BRCA and Non-BRCA HR-Gene-Variants in a Cohort of Pancreatic Cancer Patients.Semantic proximity Read ↗

ATM Serine/Threonine Kinase and its Role in Pancreatic RiskSemantic proximity Read ↗

Genome-Wide Analysis of Promoter Methylation Associated with Gene Expression Profile in Pancreatic AdenocarcinomaSemantic proximity Read ↗

Methylation profile of circulating plasma DNA in patients with pancreatic cancerSemantic proximity Read ↗

The sunset of somatic genetics and the dawn of epigenetics: a new frontier in pancreatic cancer research.Semantic proximity Read ↗

Preliminary Study Analyzing the Methylated Genes in the Plasma of Patients with Pancreatic CancerSemantic proximity Read ↗

DNA Hypermethylation as a Blood-Based Marker for Pancreatic Cancer: A Literature Review.Semantic proximity Read ↗

Clinical significance of promoter methylation status of tumor suppressor genes in circulating DNA of pancreatic cancer patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.