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Article

The sunset of somatic genetics and the dawn of epigenetics: a new frontier in pancreatic cancer research.

Current opinion in gastroenterology - 1 Sept 2008

Lomberk Gwen, Mathison Angela J, Grzenda Adrienne, Urrutia Raul

Abstract excerpt

PURPOSE OF REVIEW: The excitement of finding a cancer modulator which is either mutated or deleted in vivo (genetics), unfortunately, is shadowed by the fact that we scientists have failed to live to the promise of gene therapy, and therefore, these genes cannot be replaced to cure the patients. On the contrary, both DNA methylation and chromatin-mediated inactivation of tumor suppressor genes (epigenetics), for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19122501
DOI: 10.1097/MOG.0b013e32830b111d
PMCID: PMC2941574

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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