Article
Hexokinase 2 discerns a novel circulating tumor cell population associated with poor prognosis in lung cancer patients.
Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 2021
Yang Liu, Yan Xiaowei, Chen Jie, Zhan Qiong, Hua Yingqi, Xu Shili, Li Ziming, Wang Zhuo, Dong Yu, Zuo Dongqing, Xue Min, Tang Yin, Herschman Harvey R, Lu Shun, Shi Qihui, Wei Wei
Abstract excerpt
Unlike other epithelial cancer types, circulating tumor cells (CTCs) are less frequently detected in the peripheral blood of non-small cell lung cancer (NSCLC) patients using epithelial marker-based detection approaches despite the aggressive nature of NSCLC. Here, we demonstrate hexokinase-2 (HK2) as a metabolic function-associated marker for the detection of CTCs. In 59 NSCLC patients bearing...
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