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Article

Addressing cellular heterogeneity in tumor and circulation for refined prognostication

15 Aug 2019

Abstract excerpt

Despite pronounced genomic and transcriptomic heterogeneity in non-small-cell lung cancer (NSCLC) not only between tumors, but also within a tumor, validation of clinically relevant gene signatures for prognostication has relied upon single-tissue samples, including 2 commercially available multigene tests (MGTs). Here we report an unanticipated impact of intratumor heterogeneity (ITH) on risk prediction of...

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PMID: 31416912
DOI: 10.1073/pnas.1907904116

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