Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intact HIV DNA decays in children with and without complete viral load suppression

4 Apr 2025

Abstract excerpt

To inform cure in children living with HIV (CWH), we elucidated the dynamics and mechanisms underlying HIV persistence during antiretroviral therapy (ART). In 120 Kenyan CWH who initiated ART between 1-12 months of age, 55 had durable viral load suppression, and 65 experienced ART interruptions. We measured plasma HIV RNA levels, CD4+ T cell count, and levels of intact and defective HIV DNA proviruses via the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS drug development and treatment
Share to HIV/AIDS Research and Interventions
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40184428
DOI: 10.1371/journal.ppat.1013003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intact HIV DNA decays in children with and without complete viral load suppressionPMID 40184428Read ↗

Antiretroviral therapy reveals triphasic decay of intact SIV genomes and persistence of ancestral variantsSemantic proximity Read ↗

Genetic Diversity, Compartmentalization, and Age of HIV Proviruses Persisting in CD4+ T Cell Subsets during Long-Term Combination Antiretroviral Therapy.Semantic proximity Read ↗

HIV Proviral Burden, Genetic Diversity, and Dynamics in Viremic Controllers Who Subsequently Initiated Suppressive Antiretroviral Therapy.Semantic proximity Read ↗

HIV-1 DNA Decay Dynamics in Blood During More Than a Decade of Suppressive Antiretroviral TherapySemantic proximity Read ↗

Rapid biphasic decay of intact and defective HIV DNA reservoir during acute treated HIV diseaseSemantic proximity Read ↗

HIV ‐1 DNA decay is faster in children who initiate ART shortly after birth than laterSemantic proximity Read ↗

HIV reservoirs are dominated by genetically younger and clonally enriched provirusesSemantic proximity Read ↗

Differential decay of intact and defective proviral DNA in HIV-1–infected individuals on suppressive antiretroviral therapySemantic proximity Read ↗

Impact of misclassified defective proviruses on HIV reservoir measurementsSemantic proximity Read ↗

Differences in HIV-1 reservoir size, landscape characteristics, and decay dynamics in acute and chronic treated HIV-1 Clade C infectionSemantic proximity Read ↗

Complex decay dynamics of HIV virions, intact and defective proviruses, and 2LTR circles following initiation of antiretroviral therapySemantic proximity Read ↗

Rapid Biphasic Decay of Intact and Defective HIV DNA Reservoir During Acute Treated HIV DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.