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Article

Clonal Hematopoiesis and Risk of New-Onset Myocarditis and Pericarditis.

JAMA cardiology - 1 Nov 2025

Schuermans Art, Flynn Spencer, Niroula Abhishek, Uddin Md Mesbah, Sinnaeve Peter, Budts Werner, Conrad Nathalie, Ebert Benjamin L, Libby Peter, Lin Amy E, Weber Brittany N, Natarajan Pradeep, Honigberg Michael C

Abstract excerpt

Importance: Clonal hematopoiesis of indeterminate potential (CHIP) is the age-related clonal expansion of hematopoietic stem cells with leukemia-associated mutations. Certain CHIP mutations promote atherosclerosis and heart failure through immune-related pathways. Objective: To test whether CHIP is associated with the development of myocarditis and pericarditis. Design, Setting, and Participants: This...

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Identifiers

PMID: 40884495
DOI: 10.1001/jamacardio.2025.3369
PMCID: PMC12398771

Genes

DNMT3A
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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