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Article

Multigene assessment of genetic risk for women for two or more breast cancers.

Breast cancer research and treatment - 1 Aug 2021

Weitzel Jeffrey N, Kidd John, Bernhisel Ryan, Shehayeb Susan, Frankel Paul, Blazer Kathleen R, Turco Diana, Nehoray Bita, McGreevy Kim, Svirsky Kira, Brown Krystal, Gardiner Anna, Daly Mary, Hughes Elisha, Cummings Shelly, Saam Jennifer, Slavin Thomas P

Abstract excerpt

PURPOSE: The prevalence, penetrance, and spectrum of pathogenic variants that predispose women to two or more breast cancers is largely unknown. METHODS: We queried clinical and genetic data from women with one or more breast cancer diagnosis who received multigene panel testing between 2013 and 2018. Clinical data were obtained from provider-completed test request forms. For each gene on the panel, a...

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Share to Breast Neoplasms
Share to CDH1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PALB2 gene

Share to Genes, BRCA2

Share to Genetic Predisposition to Disease

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Share to Germ-Line Mutation

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Source

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Identifiers

PMID: 33826040
DOI: 10.1007/s10549-021-06201-y
PMCID: PMC8803157

Genes

CHEK2
PTEN
BRCA1
BRCA2
CDH1
MSH6
PALB2
TP53

Provenance

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