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Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin

7 Apr 2021

Abstract excerpt

Rationale: Cardiomyopathy is characterized by the deposition of extracellular matrix by activated resident cardiac fibroblasts called myofibroblasts. There are currently no therapeutic approaches to blunt the development of pathological fibrosis and ventricle chamber stiffening that ultimately leads to heart failure. Objective: We undertook a high-throughput screen to identify small molecule inhibitors of...

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PMID: 33825488
DOI: 10.1161/circresaha.120.317791

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