Substantial anti-gout effect conferred by common and rare dysfunctional variants of URAT1/SLC22A12.

doi:10.1093/rheumatology/keab327

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Substantial anti-gout effect conferred by common and rare dysfunctional variants of URAT1/SLC22A12.

Rheumatology (Oxford, England) - 3 Nov 2021

Toyoda Yu, Kawamura Yusuke, Nakayama Akiyoshi, Nakaoka Hirofumi, Higashino Toshihide, Shimizu Seiko, Ooyama Hiroshi, Morimoto Keito, Uchida Naohiro, Shigesawa Ryuichiro, Takeuchi Kenji, Inoue Ituro, Ichida Kimiyoshi, Suzuki Hiroshi, Shinomiya Nariyoshi, Takada Tappei, Matsuo Hirotaka

Abstract excerpt

OBJECTIVES: Gout, caused by chronic elevation of serum uric acid levels, is the commonest form of inflammatory arthritis. The causative effect of common and rare variants of ATP-binding cassette transporter G2 (ABCG2/BCRP) on gout risk has been studied, but little attention has been paid to the effect of common (rs121907892, p.W258X) and rare variants of urate transporter 1 (URAT1/SLC22A12) on gout, despite...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Gout

Share to HEK293 Cells

Share to Organic Anion Transporters

Share to Organic Cation Transport Proteins

Share to Protective Factors

Share to Uric Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 33821957
DOI: 10.1093/rheumatology/keab327
PMCID: PMC8566256

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Substantial anti-gout effect conferred by common and rare dysfunctional variants of URAT1/SLC22A12.PMID 33821957Read ↗

Dysfunctional missense variant of OAT10/SLC22A13 decreases gout risk and serum uric acid levelsSemantic proximity Read ↗

Genetic Association Between SLC22A12 Variants and Susceptibility to Hyperuricemia: A Meta-Analysis.Semantic proximity Read ↗

Common dysfunctional variants in ABCG2 are a major cause of early-onset goutSemantic proximity Read ↗

Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors.Semantic proximity Read ↗

Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population.Semantic proximity Read ↗

Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population.Semantic proximity Read ↗

Genetic variation in the ABCG2 gene is associated with gout risk in the Chinese Han population.Semantic proximity Read ↗

Multiple common and rare variants of ABCG2 cause goutSemantic proximity Read ↗

Polymorphisms of uric transporter proteins in the pathogenesis of gout in a Chinese Han population.Semantic proximity Read ↗

ABCG2/BCRP dysfunction as a major cause of gout.Semantic proximity Read ↗

The effects of URAT1/SLC22A12 nonfunctional variants,R90H and W258X, on serum uric acid levels and gout/hyperuricemia progressionSemantic proximity Read ↗

Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males: a case-control study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.