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Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population.

Human cell - 1 Mar 2021

Kawaguchi Makoto, Nakayama Akiyoshi, Aoyagi Yuka, Nakamura Takahiro, Shimizu Seiko, Kawamura Yusuke, Takao Mikiya, Tamura Takashi, Hishida Asahi, Nagayoshi Mako, Nagase Mitsuo, Ooyama Keiko, Ooyama Hiroshi, Shinomiya Nariyoshi, Matsuo Hirotaka

Abstract excerpt

Gout is a common type of acute arthritis that results from elevated serum uric acid (SUA) levels. Recent genome-wide association studies (GWASs) have revealed several novel single nucleotide polymorphism (SNPs) associated with SUA levels. Of these, rs10821905 of A1CF and rs1178977 of BAZ1B showed the greatest and the second greatest significant effect size for increasing SUA level in the Japanese population, but...

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Identifiers

PMID: 33517564
DOI: 10.1007/s13577-021-00485-4
PMCID: PMC7900071

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