Article
Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1).
Biochimica et biophysica acta - 20 Dec 2000
Sokal I, Li N, Verlinde C L, Haeseleer F, Baehr W, Palczewski K
Abstract excerpt
Examination of the role of Ca(2+)-binding proteins (CaBPs) in mammalian retinal neurons has yielded new insights into the function of these proteins in normal and pathological states. In the last 8 years, studies on guanylate cyclase (GC) regulation by three GC-activating proteins (GCAP1-3) led to several breakthroughs, among them the recent biochemical analysis of GCAP1(Y99) mutants associated with autosomal...
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