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Article

Impaired Ca2+ Sensitivity of a Novel GCAP1 Variant Causes Cone Dystrophy and Leads to Abnormal Synaptic Transmission Between Photoreceptors and Bipolar Cells.

International journal of molecular sciences - 14 Apr 2021

Marino Valerio, Dal Cortivo Giuditta, Maltese Paolo Enrico, Placidi Giorgio, De Siena Elisa, Falsini Benedetto, Bertelli Matteo, Dell'Orco Daniele

Abstract excerpt

Guanylate cyclase-activating protein 1 (GCAP1) is involved in the shutdown of the phototransduction cascade by regulating the enzymatic activity of retinal guanylate cyclase via a Ca2+/cGMP negative feedback. While the phototransduction-associated role of GCAP1 in the photoreceptor outer segment is widely established, its implication in synaptic transmission to downstream neurons remains to be clarified. Here, we...

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Identifiers

PMID: 33919796
DOI: 10.3390/ijms22084030
PMCID: PMC8070792

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Impaired Ca2+ Sensitivity of a Novel GCAP1 Variant Causes Cone Dystrophy and Leads to Abnormal Synaptic Transmission Between Photoreceptors and Bipolar Cells.PMID 33919796Read ↗

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