Article
HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis.
Proceedings of the National Academy of Sciences of the United States of America - 8 Oct 2013
Miyauchi Yoshiteru, Sato Yuiko, Kobayashi Tami, Yoshida Shigeyuki, Mori Tomoaki, Kanagawa Hiroya, Katsuyama Eri, Fujie Atsuhiro, Hao Wu, Miyamoto Kana, Tando Toshimi, Morioka Hideo, Matsumoto Morio, Chambon Pierre, Johnson Randall S, Kato Shigeaki, Toyama Yoshiaki, Miyamoto Takeshi
Abstract excerpt
In women, estrogen deficiency after menopause frequently accelerates osteoclastic bone resorption, leading to osteoporosis, the most common skeletal disorder. However, mechanisms underlying osteoporosis resulting from estrogen deficiency remain largely unknown. Here we show that in bone-resorbing osteoclasts, estrogen-dependent destabilization of hypoxia-inducible factor 1 alpha (HIF1α), which is unstable in the...
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