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Article

Potential effects of genetic variations in fusion protein on the virulence of human respiratory syncytial virus.

Frontiers in immunology - 1 Jan 2026

Song Jingjing, Wang Na, Zhu Zhen, Mao Naiying, Li Hai, Song Jinhua, Cao Lei, Xia Baicheng, Liao Min, Zhu Wuyang, Zhang Yan

Abstract excerpt

Introduction: The fusion glycoprotein (F protein) of human respiratory syncytial virus (HRSV) critically determines viral infectivity and host immune recognition. This study evaluated the effects of F protein genetic variations from the globally dominant HRSV genotypes ON1 and BA9 on viral replication dynamics and pathogenicity. Methods: Using a reverse genetics system, two recombinant HRSV strains,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42491092
DOI: 10.3389/fimmu.2026.1841974
PMCID: PMC13376264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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