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Article

Transglycosylation Activity of Engineered Bifidobacterium Lacto-N-Biosidase Mutants at Donor Subsites for Lacto-N-Tetraose Synthesis.

International journal of molecular sciences - 22 Mar 2021

Castejón-Vilatersana Mireia, Faijes Magda, Planas Antoni

Abstract excerpt

The health benefits of human milk oligosaccharides (HMOs) make them attractive targets as supplements for infant formula milks. However, HMO synthesis is still challenging and only two HMOs have been marketed. Engineering glycoside hydrolases into transglycosylases may provide biocatalytic routes to the synthesis of complex oligosaccharides. Lacto-N-biosidase from Bifidobacterium bifidum (LnbB) is a GH20 enzyme...

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PMID: 33810098
DOI: 10.3390/ijms22063230
PMCID: PMC8004761

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