Article
α-L-Fucosidases and their applications for the production of fucosylated human milk oligosaccharides.
Applied microbiology and biotechnology - 1 Jul 2020
Wan Li, Zhu Yingying, Zhang Wenli, Mu Wanmeng
Abstract excerpt
α-L-Fucosidases (EC 3.2.1.51), catalyzing the hydrolysis of fucosides and/or the transfer of fucosyl residue, have been characterized and modified into a trans-fucosylation mode or, further, engineered to function as "fucosynthase", which can be employed for the enzymatic synthesis of bioactive glycans, including fucosylated human milk oligosaccharides (HMOs). More than half of HMOs are fucosylated and have...
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