Crystal structure and structure-guided tunnel engineering in a bacterial β-1,4-galactosyltransferase.

Abstract excerpt

Lacto-N-neotetraose (LNnT), a representative oligosaccharide found in human milk, has been previously examined for its beneficial traits. However, the LNnT titer is limited by the efficient glycosyltransferase pathway, particularly with respect to the catalysis of rate-limiting steps. As data on the crystal structure of the key enzyme required for synthesizing LNnT are lacking, the synthesis of LNnT remains an...

Topics

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• Catalytic Domain
• Crystallography, X-Ray
• Galactosyltransferases
• Models, Molecular
• Oligosaccharides