Article
Design of an α-L-transfucosidase for the synthesis of fucosylated HMOs.
Glycobiology - 1 Mar 2016
Saumonneau Amélie, Champion Elise, Peltier-Pain Pauline, Molnar-Gabor Dora, Hendrickx Johann, Tran Vinh, Hederos Markus, Dekany Gyula, Tellier Charles
Abstract excerpt
Human milk oligosaccharides (HMOs) are recognized as benefiting breast-fed infants in multiple ways. As a result, there is growing interest in the synthesis of HMOs mimicking their natural diversity. Most HMOs are fucosylated oligosaccharides. α-l-Fucosidases catalyze the hydrolysis of α-l-fucose from the non-reducing end of a glucan. They fall into the glycoside hydrolase GH29 and GH95 families. The GH29 family...
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