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Article

Reciprocal regulation between O-GlcNAcylation and tribbles pseudokinase 2 (TRIB2) maintains transformative phenotypes in liver cancer cells.

Cellular signalling - 1 Nov 2016

Yao Bingjie, Xu Yanli, Wang Jiayi, Qiao Yongxia, Zhang Yue, Zhang Xiao, Chen Yan, Wu Qi, Zhao Yinghui, Zhu Guoqing, Sun Fenyong, Li Zhi, Yuan Hong

Abstract excerpt

TRIB2 has been identified as an onco-protein, and O-GlcNAcylation of target proteins has been reported to stimulate transformative phenotypes in liver cancer cells. However, the relationships between TRIB2 and O-GlcNAcylation are still unknown. The aim of this study was to investigate whether and how O-GlcNAcylation and TRIB2 regulate each other. We found that stimulation of O-GlcNAcylation elevates TRIB2 by...

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Source

Identifiers

PMID: 27515988
DOI: 10.1016/j.cellsig.2016.08.003

Genes

TRIB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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