Article
Non-neutralizing Antibodies May Contribute to Suppression of SIVmac239 Viremia in Indian Rhesus Macaques.
Frontiers in immunology - 1 Jan 2021
Pedreño-Lopez Nuria, Rosen Brandon C, Flores Walter J, Gorman Matthew J, Voigt Thomas B, Ricciardi Michael J, Crosno Kristin, Weisgrau Kim L, Parks Christopher L, Lifson Jeffrey D, Alter Galit, Rakasz Eva G, Magnani Diogo M, Martins Mauricio A, Watkins David I
Abstract excerpt
The antiviral properties of broadly neutralizing antibodies against HIV are well-documented but no vaccine is currently able to elicit protective titers of these responses in primates. While current vaccine modalities can readily induce non-neutralizing antibodies against simian immunodeficiency virus (SIV) and HIV, the ability of these responses to restrict lentivirus transmission and replication remains...
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