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Article

Genetically predicted serum urate levels have no causal role on depression or other psychiatric disorders.

Clinical rheumatology - 1 Sept 2021

Zhao Sizheng Steven, Qian Yu, Mackie Sarah L, Wen Chengping, Mao Yingying

Abstract excerpt

Clinicians are advised caution in reducing serum urate for gout management due to observational associations with risk of neuropsychiatric diseases. We examined the causal effect of genetically predicted serum urate levels on the risk of major depressive disorder (MDD), anxiety, and related psychiatric disorders using two-sample Mendelian randomization (MR). We identified single-nucleotide polymorphisms (SNPs)...

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Identifiers

PMID: 33786690
DOI: 10.1007/s10067-021-05718-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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