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Article

Genetically high plasma vitamin C and urate: a Mendelian randomization study in 106 147 individuals from the general population.

Rheumatology (Oxford, England) - 1 Oct 2018

Kobylecki Camilla J, Afzal Shoaib, Nordestgaard Børge G

Abstract excerpt

Objective: Gout is the most common form of inflammatory arthritis and is caused by hyperuricaemia. Some studies have found a reduction in plasma urate with vitamin C supplementation. We tested the hypothesis that high plasma vitamin C is causally associated with low plasma urate and low risk of hyperuricaemia, using a Mendelian randomization approach. Methods: We measured plasma urate and genotyped for the...

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PMID: 29939348
DOI: 10.1093/rheumatology/key171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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