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Article

A Wnt-mediated phenotype switch along the epithelial-mesenchymal axis defines resistance and invasion downstream of ionising radiation in oral squamous cell carcinoma.

British journal of cancer - 1 Jun 2021

Zolghadr Fatemeh, Tse Nigel, Loka Dikasya, Joun George, Meppat Sreelakshmi, Wan Victor, Zoellner Hans, Xaymardan Munira, Farah Camile S, Lyons J Guy, Hau Eric, Patrick Ellis, Seyedasli Naisana

Abstract excerpt

BACKGROUND: Dynamic transitions of tumour cells along the epithelial-mesenchymal axis are important in tumorigenesis, metastasis and therapy resistance. METHODS: In this study, we have used cell lines, 3D spheroids and tumour samples in a variety of cell biological and transcriptome analyses to highlight the cellular and molecular dynamics of OSCC response to ionising radiation. RESULTS: Our study demonstrates a...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33785878
DOI: 10.1038/s41416-021-01352-7
PMCID: PMC8184921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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