Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EGFR-mediated local invasiveness and response to Cetuximab in head and neck cancer

22 Mar 2025

Abstract excerpt

BACKGROUND: Recurrent/metastatic head and neck squamous cell carcinoma (R/M-HNSCC) is a severe, frequently lethal condition. Oncogene addiction to epidermal growth factor receptor (EGFR) is a hallmark of HNSCC, but the clinical efficacy of EGFR-targeted therapies remains low. Understanding molecular networks governing EGFR-driven progression is paramount to the exploration of (co)-treatment targets and predictive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Caveolin-1 and cellular processes
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40121428
DOI: 10.1186/s12943-025-02290-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EGFR-mediated local invasiveness and response to Cetuximab in head and neck cancerPMID 40121428Read ↗

A transcriptomic map of EGFR-induced epithelial-to-mesenchymal transition identifies prognostic and therapeutic targets for head and neck cancerSemantic proximity Read ↗

Phenotype remodelling of HNSCC cells in the muscle invasion environment.Semantic proximity Read ↗

Mesenchymal-epithelial transition in lymph node metastases of oral squamous cell carcinoma is accompanied by ZEB1 expressionSemantic proximity Read ↗

Spatial Neuroimmune Crosstalk Driving Perineural Invasion in Head and Neck Squamous Cell CarcinomaSemantic proximity Read ↗

Functional Genomics Uncover the Biology behind the Responsiveness of Head and Neck Squamous Cell Cancer Patients to CetuximabSemantic proximity Read ↗

Functional proteomics identifies targetable cancer-associated fibroblast programs in head and neck cancerSemantic proximity Read ↗

Multifaceted and Intricate Oncogenic Mechanisms of NDRG1 in Head and Neck Cancer Depend on Its C-Terminal 3R-MotifSemantic proximity Read ↗

Differential transcriptional invasion signatures from patient derived organoid models define a functional prognostic tool for head and neck cancerSemantic proximity Read ↗

Neuroendocrine-like/EMT dedifferentiation mediates resistance to EGFR inhibitors via the NRG1/HER3 axisSemantic proximity Read ↗

Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome.Semantic proximity Read ↗

Annexin A1 regulates EGFR activity and alters EGFR-containing tumour-derived exosomes in head and neck cancers.Semantic proximity Read ↗

Co-expression of NRP1 and p-EGFR in the prognosis of patients with head and neck squamous cell carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.