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Killing by Degradation: Regulation of Apoptosis by the Ubiquitin-Proteasome-System

8 Dec 2021

Abstract excerpt

Apoptosis is a cell suicide process that is essential for development, tissue homeostasis and human health. Impaired apoptosis is associated with a variety of human diseases, including neurodegenerative disorders, autoimmunity and cancer. As the levels of pro- and anti-apoptotic proteins can determine the life or death of cells, tight regulation of these proteins is critical. The ubiquitin proteasome system (UPS)...

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PMID: 34943974
DOI: 10.3390/cells10123465

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