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Article

A Triptolide Loaded HER2-Targeted Nano-Drug Delivery System Significantly Suppressed the Proliferation of HER2-Positive and BRAF Mutant Colon Cancer.

International journal of nanomedicine - 1 Jan 2021

Yalikong Ayimukedisi, Li Xu-Quan, Zhou Ping-Hong, Qi Zhi-Peng, Li Bing, Cai Shi-Lun, Zhong Yun-Shi

Abstract excerpt

BACKGROUND: Colon cancer (CRC) was a malignant tumor and there were about 25% of patients with tumor metastasis at diagnosis stage. Chemotherapeutic agents for metastatic CRC patients were with great side effects and the clinical treatment results of advanced CRC were still not satisfactory. Human epidermal growth factor receptor 2 (HER2) is overexpressed in some CRC patients and is an effective target for CRC...

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PMID: 33776436
DOI: 10.2147/IJN.S287732
PMCID: PMC7989962

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