Engineering siRNA-loaded and RGDfC-targeted selenium nanoparticles for highly efficient silencing of DCBLD2 gene for colorectal cancer treatment

Abstract excerpt

Effective and safe delivery of small interfering RNA (siRNA) by nanomaterials to cancer cells is one of the main challenges in cancer treatment. In this study, we constructed the selenium nanoparticles conjugated with RGDfC (one tumor-targeted polypeptide) to prepare a biocompatible gene vector (RGDfC-SeNPs) and then loaded with siDCBLD2 to synthesize the RGDfC-Se@siDCBLD2 for colorectal cancer (CRC) therapy. As e...

Topics

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• Cell Line, Tumor
• Mice
• Mutation
• Nanoparticles
• Pancreatic Neoplasms
• Peptides
• Proto-Oncogene Proteins p21(ras)
• RNA, Small Interfering

Identifiers and source

Literature Corpus work

37e842a6-6187-57d6-b837-409a6ef63214

DOI

10.21203/rs.3.rs-2646308/v1