Article

Engineering siRNA-loaded and RGDfC-targeted selenium nanoparticles for highly efficient silencing of DCBLD2 gene for colorectal cancer treatment

2023-03-13

Abstract excerpt

Effective and safe delivery of small interfering RNA (siRNA) by nanomaterials to cancer cells is one of the main challenges in cancer treatment. In this study, we constructed the selenium nanoparticles conjugated with RGDfC (one tumor-targeted polypeptide) to prepare a biocompatible gene vector (RGDfC-SeNPs) and then loaded with siDCBLD2 to synthesize the RGDfC-Se@siDCBLD2 for colorectal cancer (CRC) therapy. As e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 37e842a6-6187-57d6-b837-409a6ef63214
DOI: 10.21203/rs.3.rs-2646308/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Engineering siRNA-loaded and RGDfC-targeted selenium nanoparticles for highly efficient silencing of DCBLD2 gene for colorectal cancer treatmentDOI 10.21203/rs.3.rs-2646308/v1Read

A comprehensive update of siRNA delivery design strategies for targeted and effective gene silencing in gene therapy and other applicationsSemantic proximity Read

Targeted nanodelivery of siRNA against KRAS G12D inhibits pancreatic cancer.Semantic proximity Read

Non-cationic RGD-containing protein carrier for tumor-targeted siRNA deliverySemantic proximity Read

Nanoformulation of Apolipoprotein E3-Tagged Liposomal Nanoparticles for the co-Delivery of KRAS-siRNA and Gemcitabine for Pancreatic Cancer Treatment.Semantic proximity Read

Optimized nanoparticle-mediated delivery of CRISPR-Cas9 system for B cell interventionSemantic proximity Read

Crispr Cas9 fluorine-containing PEI nanomedicine inhibits the growth of hepatocellular carcinoma cells by knocking out NEDD8-E2 conjugase UBC12 (UBE2M)Semantic proximity Read

Multi-protein silencing using WRAP-based nanoparticles: a proof of conceptSemantic proximity Read

Targeted Gene-Hormone Therapy of Colorectal Cancer with Guanylin Expressing Nano-system: In Silico and In Vitro StudySemantic proximity Read

Cationic lipid-assisted polymeric nanoparticle mediated GATA2 siRNA delivery for synthetic lethal therapy of KRAS mutant non-small-cell lung carcinoma.Semantic proximity Read

Targeted Gene-Hormone Therapy of Colorectal Cancer with Guanylin Expressing Nano-systemSemantic proximity Read

Cellular Uptake and Fate of Cationic Polymer-Coated Nanodiamonds Delivering siRNA: A Mechanistic StudySemantic proximity Read

Nanoparticles co-delivering siRNA and mRNA for simultaneous restoration and silencing of gene/protein expression <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read