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Article

G-quadruplex in hepatitis B virus pregenomic RNA promotes its translation.

The Journal of biological chemistry - 1 Sept 2023

Wang Jingjing, Huang Haiyan, Zhao Kaitao, Teng Yan, Zhao Li, Xu Zaichao, Zheng Yingcheng, Zhang Lu, Li Conghui, Duan Yurong, Liang Kaiwei, Zhou Xiang, Cheng Xiaoming, Xia Yuchen

Abstract excerpt

Hepatitis B virus (HBV) is a hepatotropic DNA virus that has a very compact genome. Due to this genomic density, several distinct mechanisms are used to facilitate the viral life cycle. Recently, accumulating evidence show that G-quadruplex (G4) in different viruses play essential regulatory roles in key steps of the viral life cycle. Although G4 structures in the HBV genome have been reported, their function in...

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Identifiers

PMID: 37567479
DOI: 10.1016/j.jbc.2023.105151
PMCID: PMC10485161

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