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Article

Association between the nucleosome footprint of plasma DNA and neoadjuvant chemotherapy response for breast cancer

26 Mar 2021

Abstract excerpt

Gene expression signatures have been used to predict the outcome of chemotherapy for breast cancer. The nucleosome footprint of cell-free DNA (cfDNA) carries gene expression information of the original tissues and thus may be used to predict the response to chemotherapy. Here we carried out the nucleosome positioning on cfDNA from 85 breast cancer patients and 85 healthy individuals and two cancer cell lines...

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PMID: 33772032
DOI: 10.1038/s41523-021-00237-5

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