Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolutionary study of leporid CD4 reveals a hotspot of genetic variability within the D2 domain.

Immunogenetics - 1 Jul 2016

de Sousa-Pereira Patricia, Abrantes Joana, Baldauf Hanna-Mari, Keppler Oliver T, Esteves Pedro J

Abstract excerpt

CD4 is the major receptor on T helper cells involved in the uptake of human immunodeficiency virus (HIV) or simian immunodeficiency virus (SIV) into their host cells. Evolutionary studies of CD4 in primates revealed signatures of positive selection in the D1 domain that interacts with primate exogenous lentivirus gp120 proteins. Here, we studied the evolution of CD4 in lagomorphs by comparing sequences obtained...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Biological Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4 Antigens

Share to Genetic Variation

Share to Protein Domains

Share to Rabbits

Share to Sequence Homology, Amino Acid

Source

Identifiers

PMID: 26979977
DOI: 10.1007/s00251-016-0909-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolutionary study of leporid CD4 reveals a hotspot of genetic variability within the D2 domain.PMID 26979977Read ↗

CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses.Semantic proximity Read ↗

Ancient convergence with prokaryote defense and recent adaptations to lentiviruses in primates characterize the ancestral immune factors SAMD9sSemantic proximity Read ↗

Host gene evolution traces the evolutionary history of ancient primate lentivirusesSemantic proximity Read ↗

Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency virusesSemantic proximity Read ↗

Sequencing of Sylvilagus VDJ genes reveals a new VHa allelic lineage and shows that ancient VH lineages were retained differently in leporids.Semantic proximity Read ↗

Leporid immunoglobulin G shows evidence of strong selective pressure on the hinge and CH3 domains.Semantic proximity Read ↗

Convergence and divergence in the evolution of the APOBEC3G-Vif interaction reveal ancient origins of simian immunodeficiency viruses.Semantic proximity Read ↗

Identifying Candidate Genetic Markers of CDV Cross-Species Pathogenicity in African LionsSemantic proximity Read ↗

Evolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus RestrictionSemantic proximity Read ↗

Evolution of CCL11: genetic characterization in lagomorphs and evidence of positive and purifying selection in mammals.Semantic proximity Read ↗

The evolution of HIV-1 and the origin of AIDSSemantic proximity Read ↗

Identification of a RELIK orthologue in the European hare (Lepus europaeus) reveals a minimum age of 12 million years for the lagomorph lentiviruses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.