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Article

Lipid Storage and Interferon Response Determine the Phenotype of Ground Glass Hepatocytes in Mice and Humans.

Cellular and molecular gastroenterology and hepatology - 1 Jan 2021

Churin Yuri, Irungbam Karuna, Imiela Christoph S, Schwarz David, Mollenkopf Hans-Joachim, Drebber Uta, Odenthal Margarete, Pak Oleg, Huber Magdalena, Glebe Dieter, Roderfeld Martin, Roeb Elke

Abstract excerpt

BACKGROUND AND AIMS: A histopathological hallmark of chronic hepatitis B virus (HBV) infection is the presence of ground glass hepatocytes (GGHs). GGHs are liver cells that exhibit eosinophilic, granular, glassy cytoplasm in light microscopy and are characterized by accumulation of HBV surface (HBs) proteins in the endoplasmic reticulum (ER). More important, GGHs have been accepted as a precursor of HCC and may...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33766783
DOI: 10.1016/j.jcmgh.2021.03.009
PMCID: PMC8255940

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