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Identifying the major lactate transporter of Toxoplasma gondii tachyzoites

24 Mar 2021

Abstract excerpt

Toxoplasma gondii and Plasmodium falciparum parasites both extrude L-lactate, a byproduct of glycolysis. The P. falciparum Formate Nitrite Transporter, PfFNT, mediates L-lactate transport across the plasma membrane of P. falciparum parasites and has been validated as a drug target. The T. gondii genome encodes three FNTs that have been shown to transport L-lactate, and which are proposed to be the targets of...

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PMID: 33762657
DOI: 10.1038/s41598-021-86204-3

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