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Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentiality

1 Feb 2010

Abstract excerpt

A Plasmodium falciparum hexose transporter (PfHT) has previously been shown to be a facilitative glucose and fructose transporter. Its expression in Xenopus laevis oocytes and the use of a glucose analogue inhibitor permitted chemical validation of PfHT as a novel drug target. Following recent re-annotations of the P. falciparum genome, other putative sugar transporters have been identified. To investigate...

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PMID: 20132450
DOI: 10.1111/j.1365-2958.2010.07060.x

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