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Article

Lactate dehydrogenase in Toxoplasma gondii controls virulence, bradyzoite differentiation, and chronic infection.

PloS one - 1 Jan 2017

Abdelbaset Abdelbaset E, Fox Barbara A, Karram Mohamed H, Abd Ellah Mahmoud R, Bzik David J, Igarashi Makoto

Abstract excerpt

In the asexual stages, Toxoplasma gondii stage converts between acute phase rapidly replicating tachyzoites and chronic phase slowly dividing bradyzoites. Correspondingly, T. gondii differentially expresses two distinct genes and isoforms of the lactate dehydrogenase enzyme, expressing LDH1 exclusively in the tachyzoite stage and LDH2 preferentially in the bradyzoite stage. LDH catalyzes the interconversion of...

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Identifiers

PMID: 28323833
DOI: 10.1371/journal.pone.0173745
PMCID: PMC5360243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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